I take things as they come--and therefore am terrible at ranking anything, unless it's traumatized my in its awfulness or something.
I can't say Despicable Me is the absolute funniest movie I've ever scene, because I've never been able to keep track of such things.
However, Gru was far more amusing than I expected, and the trailers really didn't do it justice. The minions managed to stay on just this side of cute without (too often) becoming completely irritating...a fairly significant feat, considering they were very nearly irrelevant to the movie.
I loved the names of the girls, too. Margo, Edith, and Agnes, and their growing relationship with Gru as "Daddy" was actually remarkable touching.
While the humor was the level you'd expect from this kind of movie, the timing really helped it work for me.